Soluble Guanylyl Cyclase

A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.

Also Known As:

Nitric Oxide Receptor; Nitric Oxide Receptors; Nitric Oxide-Sensitive Guanylyl Cyclase; Receptor, Nitric Oxide; Soluble Guanylate Cyclase; Soluble Guanylyl Cyclase, alpha Subunit; Soluble Guanylyl Cyclase, beta Subunit; Cyclase, Soluble Guanylate; Cyclase, Soluble Guanylyl; Guanylate Cyclase, Soluble; Guanylyl Cyclase, Soluble; Nitric Oxide Sensitive Guanylyl Cyclase; Oxide Receptor, Nitric; Oxide Receptors, Nitric

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Lyases: 659
    - Phosphorus-Oxygen Lyases
      - Guanylate Cyclase: 701
        Soluble Guanylyl Cyclase: 798
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Intracellular Signaling Peptides and Proteins: 32
    - Guanylate Cyclase: 701
      - Soluble Guanylyl Cyclase: 798

Alfredo Augusto Vasconcelos-Silva Selected Research

Alfredo Augusto Vasconcelos-Silva Research Topics

Disease

Drug/Important Bio-Agent (IBA)